Hot Flashes are the most common complaint in women entering menopause with symptoms of transient sensations of heat, flushing and sweating frequently lasting 4 to 10 minutes and followed with a feeling of being chilled and may be accompanied with other symptoms as well. For many women, this may continue for up to 5 years although 20% of women may continue to experience them for up to 15 years.
The most common and effective treatment used for hot flashes has always been hormone replacement therapy (HRT). But the Women's Health Initiative studies raise many questions about the long-term safety of HRT therapy. Current guidelines recommend very limited duration of HRT therapy due to many associated risks. Hot Flashes can have a significant negative impact on quality of life and are therefore a major reason for menopausal women to seek medical attention.
This clinical study ins an innovative new mechanism of action which is a "non-hormonal" treatment specifically targeting the cause of hot flashes.
The purpose of the study is to see how effective, safe and tolerable the investigational drug is compared to a placebo on the frequency and severity of moderately to severe vasomotor (VMS) symptoms "hot flashes "in post-menopausal women.